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Immunologie et infection

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慢性沙门氏菌感染诱发肠纤维化

Journal JoVE
Immunologie et infection

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Journal JoVE Immunologie et infection

Chronic Salmonella Infection Induced Intestinal Fibrosis

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慢性沙门氏菌感染诱发肠纤维化

6,674 Views

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08:40 min

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September 22, 2019

DOI:

10.3791/60068-v

DOI:

10.3791/60068-v

•

08:40 min

September 22, 2019

•

8 Views

Bernard C. Lo¹, Samuel B. Shin¹, Melina Messing¹, Kelly M. McNagny¹

¹The Biomedical Research Centre,University of British Columbia

Summary

该协议描述了沙门氏菌驱动的肠道纤维化的小鼠模型，类似于克罗恩病的关键病理特征，包括跨体炎症和纤维化。该方法可用于评估使用维持在C57Bl/6遗传背景的突变小鼠改变纤维化结果的宿主因素。

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