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在免疫缺陷小鼠中表演人类骨骼肌异种移植物

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Biologie du développement

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Journal JoVE Biologie du développement

Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

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在免疫缺陷小鼠中表演人类骨骼肌异种移植物

9,445 Views

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07:48 min

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September 16, 2019

DOI:

10.3791/59966-v

DOI:

10.3791/59966-v

•

07:48 min

September 16, 2019

•

10 Views

Kyla A. Britson^1,2, Aaron D. Black^2,3, Kathryn R. Wagner^1,2,3,4, Thomas E. Lloyd^1,2,4

¹Graduate Program in Cellular and Molecular Medicine,Johns Hopkins University School of Medicine, ²Department of Neurology,Johns Hopkins University School of Medicine, ³Kennedy Krieger Institute, ⁴Department of Neuroscience,Johns Hopkins University School of Medicine

Summary

在传统的实验室模型系统中，复杂的人类疾病对建模可能具有挑战性。在这里，我们描述了一种通过将人类骨骼肌活检移植到免疫缺陷小鼠中来模拟人类肌肉疾病的外科方法。

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