Journal
/
Bio-ingénierie
/
Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix
Journal JoVE
Bio-ingénierie
Un abonnement à JoVE est nécessaire pour voir ce contenu.  Connectez-vous ou commencez votre essai gratuit.
Journal JoVE Bio-ingénierie
Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix

Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix

DOI:
10.3791/51390-v

•

09:11 min

•

September 22, 2014

•

, , , ,
1Cardiology, Department of Medicine,University of Fribourg

Chapitres

  • 00:05Titre
  • 01:15Mesenchymal Stem Cell Isolation from Bone Marrow Protocol
  • 02:41First Thoracotomy and Ligation of Left Anterior Descending Coronary Artery
  • 05:19Epicardial Administration of the Treatment Via a Second Thoracotomy
  • 06:50Results: Procedure Illustation and Post-operative Evaluation
  • 08:40Conclusion

Summary

Traduction automatique

Traduction automatique

Implantation of a biograft to treat myocardial infarction induced by LAD ligation in a rodent model has conventionally required two open-heart surgeries. In order to reduce mortality and provide optimal conditions for fixation of solid and gelatinous biomatrices associated with cells, minimally invasive procedures have been developed.

Tags

Keywords: Cell-based TherapyHeart FailureRat ModelMyocardial InfarctionLAD LigationThoracotomyEpicardial ImplantationBiomaterialsCell DeliveryMinimally Invasive SurgeryEchocardiographyGoldner Trichrome StainingPost-operative Mortality

Article

Embed

AJOUTER À LA PLAYLIST

Usage Statistics

Vidéos Connexes

check_url/fr/51390?article_type=v

Bioluminescence Imaging for Assessment of Immune Responses Following Implantation of Engineered Heart Tissue (EHT)
check_url/fr/51390?article_type=v

Optical Mapping of Action Potentials and Calcium Transients in the Mouse Heart
check_url/fr/51390?article_type=v

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
check_url/fr/51390?article_type=v

Analysis of Tubular Membrane Networks in Cardiac Myocytes from Atria and Ventricles
check_url/fr/51390?article_type=v

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
check_url/fr/51390?article_type=v

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates
check_url/fr/51390?article_type=v

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
check_url/fr/51390?article_type=v

Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair
check_url/fr/51390?article_type=v

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction
check_url/fr/51390?article_type=v

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Read Article