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Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix
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JoVE Revista Bioingeniería
Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix

Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix

DOI:
10.3791/51390-v

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09:11 min

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September 22, 2014

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, , , ,
1Cardiology, Department of Medicine,University of Fribourg

Capítulos

  • 00:05Título
  • 01:15Mesenchymal Stem Cell Isolation from Bone Marrow Protocol
  • 02:41First Thoracotomy and Ligation of Left Anterior Descending Coronary Artery
  • 05:19Epicardial Administration of the Treatment Via a Second Thoracotomy
  • 06:50Results: Procedure Illustation and Post-operative Evaluation
  • 08:40Conclusion

Summary

Traducción Automática

Traducción Automática

Implantation of a biograft to treat myocardial infarction induced by LAD ligation in a rodent model has conventionally required two open-heart surgeries. In order to reduce mortality and provide optimal conditions for fixation of solid and gelatinous biomatrices associated with cells, minimally invasive procedures have been developed.

Tags

Keywords: Cell-based TherapyHeart FailureRat ModelMyocardial InfarctionLAD LigationThoracotomyEpicardial ImplantationBiomaterialsCell DeliveryMinimally Invasive SurgeryEchocardiographyGoldner Trichrome StainingPost-operative Mortality

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