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Generazione di un nuovo vaccino a cellule dendritiche con melanoma e cellule staminali tumorali squamose
Journal JoVE
Immunologie et infection
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Journal JoVE Immunologie et infection
Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
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Generazione di un nuovo vaccino a cellule dendritiche con melanoma e cellule staminali tumorali squamose

10,949 Views

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12:43 min

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January 06, 2014

DOI:

10.3791/50561-v

DOI:
10.3791/50561-v

•

12:43 min
January 06, 2014

•

3 Views
, , , , , , , , ,
1Department of Surgery,University of Michigan, 2Department of Internal Medicine,University of Michigan, 3Department of Otolaryngology,University of Michigan

Summary

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Valutato in ospiti immunocompetenti sigeneici, il vaccino a cellule dendritiche (DC) a base di cellule staminali tumorali (CSC) ha dimostrato un'immunità antitumorale significativamente più elevata rispetto ai tradizionali vaccini CC pulsati con cellule tumorali alla rinfusa eterogenee.

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Cancer Stem CellsDendritic Cell VaccineMelanomaSquamous CancerALDHAntitumor ImmunityIFN-γGM-CSF

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Li, Q., Lu, L., Tao, H., Xue, C., Teitz-Tennenbaum, S., Owen, J. H., Moyer, J. S., Prince, M. E., Chang, A. E., Wicha, M. S. Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells. J. Vis. Exp. (83), e50561, doi:10.3791/50561 (2014).

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