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Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
JoVE Revista
Inmunología y contagio
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JoVE Revista Inmunología y contagio
Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

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12:43 min

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January 06, 2014

DOI:

10.3791/50561-v

DOI:
10.3791/50561-v

•

12:43 min
January 06, 2014

•

3 Views
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1Department of Surgery,University of Michigan, 2Department of Internal Medicine,University of Michigan, 3Department of Otolaryngology,University of Michigan

Summary

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Evaluated in syngeneic immunocompetent hosts, cancer stem cell (CSC) based dendritic cell (DC) vaccine demonstrated significantly higher antitumor immunity than traditional DC vaccines pulsed with heterogeneous bulk tumor cells.

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Cancer Stem CellsDendritic Cell VaccineMelanomaSquamous CancerALDHAntitumor ImmunityIFN-γGM-CSF

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Li, Q., Lu, L., Tao, H., Xue, C., Teitz-Tennenbaum, S., Owen, J. H., Moyer, J. S., Prince, M. E., Chang, A. E., Wicha, M. S. Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells. J. Vis. Exp. (83), e50561, doi:10.3791/50561 (2014).

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