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Construction de peptides cycliques à l’aide d’un centre de sulfonium sur attache
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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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Construction de peptides cycliques à l’aide d’un centre de sulfonium sur attache

2,423 Views

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07:11 min

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September 28, 2022

DOI:

10.3791/64289-v

DOI:
10.3791/64289-v

•

07:11 min
September 28, 2022

•

6 Views
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1Pingshan Translational Medicine Center,Shenzhen Bay Laboratory, 2Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School, 3Department of Radiation Oncology, the First Affiliated Hospital,Anhui Medical University

Summary

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Ce protocole présente la synthèse de peptides cycliques via la bisalkylation entre la cystéine et la méthionine et la réaction thiol-yne facile déclenchée par le centre propargylsulfonium.

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Cite this Article

Song, C., Hou, Z., Jiao, Z., Liu, Z., Lian, C., Zhang, M., Liang, W., Yin, F., Li, Z. Constructing Cyclic Peptides Using an On-Tether Sulfonium Center. J. Vis. Exp. (187), e64289, doi:10.3791/64289 (2022).

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