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Immunology and Infection

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JoVE Journal Immunology and Infection
A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
 

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Article DOI: 10.3791/59015-v • 09:15 min • February 28th, 2019
February 28th, 2019 •
1, 1, 1, 2, 1
1Department of Biomedical Engineering, University of California Davis, 2Department of Dermatology, Johns Hopkins University School of Medicine

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An approach is described for real-time detection of the innate immune response to cutaneous wounding and Staphylococcus aureus infection of mice. By comparing LysM-EGFP mice (which possess fluorescent neutrophils) with a LysM-EGFP crossbred immunodeficient mouse strain, we advance our understanding of infection and the development of approaches to combat infection.

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Mouse Model Innate Immune Response Staphylococcus Aureus Infection Bacteria Burden Neutrophil Response Treatment Strategies Live Host Wound Placement Skin Excision Staph Aureus Inoculation Bioluminescence Staph Aureus Strain Bovine Blood Agar Plate Overnight Incubation Tryptic Soy Broth (TSB) Chloramphenicol Culture Sample Dilution Optical Density DPBS (Dulbecco's Phosphate-Buffered Saline)
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