/
/
A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
Se requiere una suscripción a JoVE para ver este contenido. Inicie sesión o comience su prueba gratuita.
A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
10,361 Views
•
07:04 min
•
August 19, 2018
DOI:
Summary
Automatically generated
Alterations in the kynurenine pathway (KP) neuroactive metabolites are implicated in psychiatric illnesses. Investigating the functional outcomes of an altered kynurenine pathway metabolism in vivo in rodents may help elucidate novel therapeutic approaches. The current protocol combines biochemical and behavioral approaches to investigate the impact of an acute kynurenine challenge in rats.
Read Article
Cite this Article
Baratta, A. M., Viechweg, S. S., Mong, J. A., Pocivavsek, A. A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats. J. Vis. Exp. (138), e58129, doi:10.3791/58129 (2018).
Copy