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Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
JoVE Revista
Inmunología y contagio
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JoVE Revista Inmunología y contagio
Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

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07:55 min

August 29, 2017

DOI:

07:55 min
August 29, 2017

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Summary

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We describe a method by which we identify critical residues required for the binding of human or murine monoclonal antibodies that target the viral hemagglutinin of influenza A viruses. The protocol can be adapted to other virus surface glycoproteins and their corresponding neutralizing antibodies.

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