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Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
JoVE 杂志
免疫与感染
This content is Free Access.
JoVE 杂志 免疫与感染
Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

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07:55 min

August 29, 2017

DOI:

07:55 min
August 29, 2017

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Summary

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We describe a method by which we identify critical residues required for the binding of human or murine monoclonal antibodies that target the viral hemagglutinin of influenza A viruses. The protocol can be adapted to other virus surface glycoproteins and their corresponding neutralizing antibodies.

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