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Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
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Capítulos
- 00:05Título
- 01:05Embryo Collection and Transgenic Embryo Screening
- 03:07Medaka-larvae Bisphosphonate Treatment
- 04:24Live Medaka-larvae Imaging
- 05:56Results: Representative Transgenic Marker Expression Analyses in 12 – 15 DPF Medaka-larvae
- 07:24Conclusion
Small laboratory fish have become popular models for bone research on the mechanisms underlying human bone disorders and for the screening of bone-modulating drugs. In this report, we describe a protocol to assess the effect of alendronate on bone cells in medaka larvae with osteoporotic lesions.
