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و<em> في المختبر</em> نموذج لدراسة الفيزيولوجيا المرضية الخلوي في الخلية حثل المادة البيضاء الكروي
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An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
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و<em> في المختبر</em> نموذج لدراسة الفيزيولوجيا المرضية الخلوي في الخلية حثل المادة البيضاء الكروي

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07:45 min

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October 21, 2014

DOI:

10.3791/51903-v

DOI:
10.3791/51903-v

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07:45 min
October 21, 2014

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1 Views
, , ,
1Department of Neuroscience,University of Connecticut Health Center, 2Department of Anatomy and Cell Biology,University of Illinois at Chicago

Summary

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Globoid cells are a defining pathological feature of Krabbe disease, a leukodystrophy currently lacking an effective long-term therapy. We have developed a cell culture model to study the innate biology and pathogenic potential of activated microglia and their transformation into globoid cells.

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Claycomb, K. I., Johnson, K. M., Bongarzone, E. R., Crocker, S. J. An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy. J. Vis. Exp. (92), e51903, doi:10.3791/51903 (2014).

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