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March 10, 2023
DOI:
1Department of Neurosurgery,Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering,Johns Hopkins University, 3HEPIUS Innovation Laboratory,Johns Hopkins University School of Medicine, 4Department of Electrical Engineering and Computer Science,Johns Hopkins University, 5Department of Mechanical Engineering,Johns Hopkins University, 6Department of Anesthesiology and Critical Care Medicine,Johns Hopkins University
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通过静脉注射微泡和应用低强度聚焦超声 （LIFU），可以成功实现血脊髓屏障 （BSCB） 的破坏。该协议详细介绍了在啮齿动物模型中使用LIFU打开BSCB，包括设备设置，微气泡注入，目标定位和BSCB破坏可视化。
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Bhimreddy, M., Routkevitch, D., Hersh, A. M., Mohammadabadi, A., Menta, A. K., Jiang, K., Weber-Levine, C., Davidar, A. D., Punnoose, J., Kempski Leadingham, K. M., Doloff, J. C., Tyler, B., Theodore, N., Manbachi, A. Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model. J. Vis. Exp. (193), e65113, doi:10.3791/65113 (2023).
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