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Targeting Alfa Synuclein aggregaten in cutane perifere zenuwvezels door Free-floating immunofluorescentie assay
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JoVE Journal Neurowissenschaften
Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
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Targeting Alfa Synuclein aggregaten in cutane perifere zenuwvezels door Free-floating immunofluorescentie assay

7,980 Views

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08:33 min

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June 25, 2019

DOI:

10.3791/59558-v

DOI:
10.3791/59558-v

•

08:33 min
June 25, 2019

•

7 Views
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1Laboratory for Biomedical Neurosciences,Neurocenter of Southern Switzerland, 2Neurology Department,Neurocenter of Southern Switzerland, 3Department of Neurology, Inselspital, Bern University Hospital,University of Bern, 4Faculty of Biomedical Sciences,Università della Svizzera Italiana

Summary

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Hier presenteren we een protocol voor een vrij zwevende indirecte immunofluorescentie assay op de huid biopsie secties die het mogelijk maakt voor de identificatie van de ziekte specifieke conformatie varianten van Alfa synuclein betrokken bij de ziekte van Parkinson en meerdere eiwitten van de perifere zenuwstelsel.

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Vacchi, E., Pinton, S., Kaelin-Lang, A., Melli, G. Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay. J. Vis. Exp. (148), e59558, doi:10.3791/59558 (2019).

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