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Journal / Neuroscience / Partial Optic Nerve Transection in Rats: A Model…
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Neuroscience
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JoVE Journal Neuroscience
Partial Optic Nerve Transection in Rats
 

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Article DOI: 10.3791/56272-v • 13:12 min • October 15th, 2017
October 15th, 2017 •
1, 2, 2, 3, 3, 4, 4, 3
1Aier School of Ophthalmology, Central South University, Changsha, China, 2Institute of Immunology, Tsinghua University School of Medicine, Beijing, China, 3Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China, 4Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China

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Summary
Automatic Translation

Secondary degeneration of retinal ganglion cells (RGCs) occurs commonly in glaucoma. This study describes an innovative operative approach for partial optic nerve transection. The use of this space-saving operative approach extends the model's application range, and allows exploration of secondary injury mechanisms in RGCs in a new way.

Tags

Partial Optic Nerve Transection Rats Model Operative Approach Secondary Degeneration Retinal Ganglion Cells Glaucoma Ocular Hypertension Neurodegenerative Disease Drug Administration Selective Tracers Secondary Injury Mechanisms Innovative Operation Approach Neuropathology Effective Therapy Neurotrauma CES Neurodegenerative Disease Surgical Instrument
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