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An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival
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JoVE Journal Neurowissenschaften
An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival

An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival

29,886 Views

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09:07 min

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April 25, 2011

DOI:

10.3791/2685-v

DOI:
10.3791/2685-v

•

09:07 min
April 25, 2011

•

27 Views
, , , , , , ,
1National Eye Institute,NIH, 2Ophthalmology Department,The Second Hospital of Harbin Medical University

Summary

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This protocol shows how to retrogradely label retinal ganglion cells, and how to subsequently make an optic nerve crush injury in order to analyze retinal ganglion cell survival and apoptosis. It is an experimental disease model for different types of optic neuropathy, including glaucoma.

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Optic Nerve Crush InjuryRetinal Ganglion Cell SurvivalOptic NeuropathyGlaucomaVision LossIrreversibleExperimental Disease ModelApoptosisNeuronal Death And SurvivalTherapeutic MeasuresTherapeutic ReagentsRetrograde LabelingHarvest The RetinaeRGC Survival

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Cite this Article

Tang, Z., Zhang, S., Lee, C., Kumar, A., Arjunan, P., Li, Y., Zhang, F., Li, X. An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival. J. Vis. Exp. (50), e2685, doi:10.3791/2685 (2011).

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