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在慢性淋巴细胞性白血病患者中使用甲基CpG结合域捕获法进行综合DNA甲基化分析

JoVE Journal
Genetik

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JoVE Journal Genetik

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

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在慢性淋巴细胞性白血病患者中使用甲基CpG结合域捕获法进行综合DNA甲基化分析

9,688 Views

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13:21 min

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June 16, 2017

DOI:

10.3791/55773-v

DOI:

10.3791/55773-v

•

13:21 min

June 16, 2017

•

4 Views

Santhilal Subhash¹, Meena Kanduri²

¹Department of Medical Genetics, Institute of Biomedicine,Gothenburg University, ²Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine,Gothenburg University

Summary

该工作描述了优化的甲基CpG结合结构域（MBD）测序方案和用于鉴定慢性淋巴细胞性白血病（CLL）患者中差异甲基化CpG富集区的计算管道。

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