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In Vivo Two-photon Imaging Of Experience-dependent Molecular Changes In Cortical Neurons
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In Vivo Two-photon Imaging Of Experience-dependent Molecular Changes In Cortical Neurons
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10:07 min
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January 05, 2013
DOI:
1Unit on Neural Circuits and Adaptive Behaviors, Genes Cognition and Psychosis Program,National Institute of Mental Health, 2Department of Neuroscience,Brown University – National Institutes of Health Graduate Partnership Program, 3Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience,National Institute on Alcohol Abuse and Alcoholism, 4Champalimaud Neuroscience Programme,Champalimaud Center for the Unknown
Summary
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Experience-dependent molecular changes in neurons are essential for the brain's ability to adapt in response to behavioral challenges. An in vivo two-photon imaging method is described here that allows the tracking of such molecular changes in individual cortical neurons through genetically encoded reporters.
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Cao, V. Y., Ye, Y., Mastwal, S. S., Lovinger, D. M., Costa, R. M., Wang, K. H. In Vivo Two-photon Imaging Of Experience-dependent Molecular Changes In Cortical Neurons. J. Vis. Exp. (71), e50148, doi:10.3791/50148 (2013).
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