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Costruzione di peptidi ciclici utilizzando un centro di solfonio on-tether
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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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Costruzione di peptidi ciclici utilizzando un centro di solfonio on-tether

2,423 Views

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07:11 min

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September 28, 2022

DOI:

10.3791/64289-v

DOI:
10.3791/64289-v

•

07:11 min
September 28, 2022

•

6 Views
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1Pingshan Translational Medicine Center,Shenzhen Bay Laboratory, 2Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School, 3Department of Radiation Oncology, the First Affiliated Hospital,Anhui Medical University

Summary

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Questo protocollo presenta la sintesi di peptidi ciclici tramite bisalchilazione tra cisteina e metionina e la facile reazione tiolo-yne innescata dal centro del propargil sulfinfo.

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Cite this Article

Song, C., Hou, Z., Jiao, Z., Liu, Z., Lian, C., Zhang, M., Liang, W., Yin, F., Li, Z. Constructing Cyclic Peptides Using an On-Tether Sulfonium Center. J. Vis. Exp. (187), e64289, doi:10.3791/64289 (2022).

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