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Fibroblastlardan Nöronal Progenitör Hücrelere Doğrudan Dönüşüm ve Astrositlere Farklılaşma Kullanarak Nörolojik Hastalıklar için İn vitro Modelleme
JoVE 杂志
神经科学
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JoVE 杂志 神经科学
In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes
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Fibroblastlardan Nöronal Progenitör Hücrelere Doğrudan Dönüşüm ve Astrositlere Farklılaşma Kullanarak Nörolojik Hastalıklar için İn vitro Modelleme

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11:42 min

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June 10, 2021

DOI:

10.3791/62016-v

DOI:
10.3791/62016-v

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11:42 min
June 10, 2021

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, , , , , ,
1Center for Gene Therapy,The Research Institute at Nationwide Children’s Hospital, 2College of Medicine, The Ohio State University

Tags

In Vitro ModelingNeurological DiseasesFibroblastsNeuronal Progenitor CellsAstrocytesDirect ConversionSkin BiopsyRetroviral VectorsOct3/4Klf4Sox2C-MycTransductionNeurodegenerative DiseasesCell CultureCo-culturesDisease MechanismsMedication Testing

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Dennys, C. N., Sierra-Delgado, J. A., Ray, S. S., Hartlaub, A. M., Roussel, F. S., Rodriguez, Y., Meyer, K. In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes. J. Vis. Exp. (172), e62016, doi:10.3791/62016 (2021).

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