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JoVE Journal Biochemistry
Karakterisering af individuelle protein aggregater ved infrarød Nanospektroskopi og atomkraften mikroskopi
 
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Karakterisering af individuelle protein aggregater ved infrarød Nanospektroskopi og atomkraften mikroskopi

Article DOI: 10.3791/60108-v • 12:58 min • September 12th, 2019
September 12th, 2019 •
1, 1,2, 1, 1, 1,3
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2Institute of Biotechnology, Life Sciences Center, Vilnius University, 3Cavendish Laboratory, Department of Physics, University of Cambridge

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Vi beskriver anvendelsen af infrarød nanospektroskopi og høj opløsning atomkraft mikroskopi at visualisere processen med protein selvsamling i oligomer aggregater og amyloid fibrils, som er tæt forbundet med debut og udvikling af en lang række humane neurodegenerative lidelser.

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Biokemi amyloid neurodegeneration protein aggregering atomkraften mikroskopi infrarød nanospektroskopi enkelt molekyle analyse spektroskopi
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