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Bioluminescentie beeldvorming van ontstekingsprocessen in transgene muizen Na Perifere Enten van alfa-synucleine fibrillen
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Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils
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Bioluminescentie beeldvorming van ontstekingsprocessen in transgene muizen Na Perifere Enten van alfa-synucleine fibrillen

8,384 Views

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09:32 min

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April 13, 2017

DOI:

10.3791/55503-v

DOI:
10.3791/55503-v

•

09:32 min
April 13, 2017

•

7 Views
, , , , ,
1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry,University of Alberta

Summary

Automatically generated

Perifere injectie van alfa-synucleine fibrillen in het peritoneum of de tong van Tg (M83 +/-: GFAP -Luc +/-) muizen, die humaan alfa-synucleine met familiaire A53T mutatie en vuurvlieg luciferase tot expressie brengen, kunnen neuropathologie induceren, waaronder neuroinflammatie in het centrale zenuwstelsel.

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Bioluminescence ImagingNeuroinflammationTransgenic MiceAlpha-synuclein FibrilsParkinson’s DiseaseNoninvasive MonitoringAnesthesiaIntranasal InoculationIntraperitoneal InjectionNerve InflammationNeurological Disease

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Cite this Article

Breid, S., Bernis, M. E., Tachu, J. B., Garza, M. C., Wille, H., Tamgüney, G. Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils. J. Vis. Exp. (122), e55503, doi:10.3791/55503 (2017).

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