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Verabreichung kardioaktiver Therapeutika in einem Schweine-Myokardinfarkt-Modell
JoVE Journal
Medicine
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JoVE Journal Medicine
Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model
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Verabreichung kardioaktiver Therapeutika in einem Schweine-Myokardinfarkt-Modell

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945 Views

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07:20 min

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February 10, 2023

DOI:

10.3791/64177-v

DOI:
10.3791/64177-v

•

07:20 min
February 10, 2023

•

13 Views
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1Centre for Heart Research, The Westmead Institute for Medical Research,The University of Sydney, 2Department of Cardiology,Westmead Hospital, 3Sydney Imaging, Core Research Facility,The University of Sydney, 4Department of Cardiothoracic Surgery,Liverpool Hospital

Summary

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Das vorliegende Protokoll beschreibt drei Methoden zur Verabreichung kardioaktiver Therapeutika in einem Schweinemodell. Weibliche Landrassenschweine erhielten die Behandlung entweder: (1) Thorakotomie und transepikardiale Injektion, (2) kathetergestützte transendokardiale Injektion oder (3) intravenöse Infusion über die osmotische Minipumpe der Jugularvene.

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Cite this Article

Selvakumar, D., Wilkie, E., Deshmukh, T., Ravindran, D., Kotake, Y., Lu, J., Barry, T., Tran, V., Paterson, H., Hing, A., Campbell, T., Kumar, S., Kizana, E., Chong, J. J. H. Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model. J. Vis. Exp. (192), e64177, doi:10.3791/64177 (2023).

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