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Crohn Hastalığında Mekanik Stresin Patojenik Rolünü İncelemek için TNBS Kaynaklı Bir Kemirgen Modeli
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Immunology and Infection
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JoVE Journal Immunology and Infection
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn’s Disease
Please note that all translations are automatically generated. Click here for the English version.

Crohn Hastalığında Mekanik Stresin Patojenik Rolünü İncelemek için TNBS Kaynaklı Bir Kemirgen Modeli

Türkçe

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3,315 Views

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05:08 min

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March 01, 2022

DOI:

10.3791/63499-v

DOI:
10.3791/63499-v

•

05:08 min
March 01, 2022

•

18 Views
, , , ,
1Department of Internal Medicine,the University of Texas Medical Branch, 2Department of Pathology,the University of Texas Medical Branch

Summary

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Mevcut protokol, kemirgenlerde Crohn benzeri bir kolit modelinin gelişimini açıklamaktadır. Transmural inflamasyon TNBS damlatma bölgesinde darlığa yol açar ve darlığa yakın segmentte mekanik genişleme gözlenir. Bu değişiklikler kolitte mekanik stresin incelenmesine izin verir.

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Cite this Article

Geesala, R., Lin, Y., Zhang, K., Qiu, S., Shi, X. A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease. J. Vis. Exp. (181), e63499, doi:10.3791/63499 (2022).

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