Journal
/
/
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn’s Disease
JoVE Journal
Immunology and Infection
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Immunology and Infection
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn’s Disease

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn’s Disease

3,332 Views

05:08 min

March 01, 2022

DOI:

05:08 min
March 01, 2022

18 Views
, , , ,

Summary

Automatically generated

The present protocol describes the development of a Crohn's-like colitis model in rodents. Transmural inflammation leads to stenosis at the TNBS instillation site, and mechanical enlargement is observed in the segment proximal to the stenosis. These changes allow studying mechanical stress in colitis.

Read Article