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Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
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Immunology and Infection
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JoVE Journal Immunology and Infection
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

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2,444 Views

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05:41 min

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April 06, 2022

DOI:

10.3791/63350-v

DOI:
10.3791/63350-v

•

05:41 min
April 06, 2022

•

2 Views
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1Division of Gastroenterology, Department of Internal Medicine,University of Texas Medical Branch at Galveston, 2Department of Gastroenterology,Xiangya Hospital of Central South University

Summary

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The interaction of genetic susceptibility, mucosal immunity, and intestinal microecological environment is involved in the pathogenesis of inflammatory bowel disease (IBD). In this study, we applied fecal microbiota transplantation to IL-10 deficient mice and investigated its impact on colonic inflammation and heart function.

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Xiao, Y., Zhong, X. S., Liu, X., Li, Q. Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model. J. Vis. Exp. (182), e63350, doi:10.3791/63350 (2022).

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