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Radiosíntese de 1-(2-[18F]Fluoroethyl)-L-Triptofano usando um Protocolo de Dois Passos de Um pote e Duas etapas
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JoVE Journal Chemistry
Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

Radiosíntese de 1-(2-[18F]Fluoroethyl)-L-Triptofano usando um Protocolo de Dois Passos de Um pote e Duas etapas

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2,937 Views

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08:33 min

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September 21, 2021

DOI:

10.3791/63025-v

DOI:
10.3791/63025-v

•

08:33 min
September 21, 2021

•

2 Views
, , , , , ,
1Diagnostic & Research PET/MRI Center,Nemours/Alfred I. duPont Hospital for Children, 2Department of Radiology,Nemours/Alfred I. duPont Hospital for Children, 3Department of Neurology,Nemours/Alfred I. duPont Hospital for Children, 4Department of Biomedical Research,Nemours/Alfred I. duPont Hospital for Children

Summary

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Aqui, descrevemos a radiosíntese de 1-(2-[18F]Fluoroetil)-L-triptofano, um agente de tomografia de emissão de pósitrons para estudar o metabolismo triptofano, usando uma estratégia de dois passos em um sistema de síntese radioquímica com bons rendimentos radioquímicos, alto excesso enantiomemérico e alta confiabilidade.

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Yue, X., Nikam, R. M., Kecskemethy, H. H., Kandula, V. V. R., Falchek, S. J., Averill, L. W., Langhans, S. A. Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol. J. Vis. Exp. (175), e63025, doi:10.3791/63025 (2021).

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