Radiosynthesis of 1-(2-[<sup>18</sup>F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

Xuyi Yue; Rahul M. Nikam; Heidi H. Kecskemethy; Vinay V. R. Kandula; Stephen J. Falchek; Lauren W. Averill; Sigrid A. Langhans

doi:10.3791/63025

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Radiosynthesis of 1-(2-[¹⁸F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

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化学

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JoVE Journal 化学

Radiosynthesis of 1-(2-[¹⁸F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

2,937 Views

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08:33 min

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September 21, 2021

DOI:

10.3791/63025-v

DOI:

10.3791/63025-v

•

08:33 min

September 21, 2021

•

2 Views

Xuyi Yue^1,2, Rahul M. Nikam^1,2, Heidi H. Kecskemethy^1,2, Vinay V. R. Kandula², Stephen J. Falchek³, Lauren W. Averill^1,2, Sigrid A. Langhans^1,4

¹Diagnostic & Research PET/MRI Center,Nemours/Alfred I. duPont Hospital for Children, ²Department of Radiology,Nemours/Alfred I. duPont Hospital for Children, ³Department of Neurology,Nemours/Alfred I. duPont Hospital for Children, ⁴Department of Biomedical Research,Nemours/Alfred I. duPont Hospital for Children

概要

Here, we describe the radiosynthesis of 1-(2-[¹⁸F]Fluoroethyl)-L-tryptophan, a positron emission tomography imaging agent for studying tryptophan metabolism, using a one-pot, two-step strategy in a radiochemistry synthesis system with good radiochemical yields, high enantiomeric excess, and high reliability.

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Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

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Radiosynthesis of 1-(2-[¹⁸F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol