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非人灵长类动物模型中视网膜色素上皮移植治疗退行性视网膜疾病
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
DOI:

11:20 min

June 14, 2021

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Chapters

  • 00:04Introduction
  • 01:22Vitrectomy
  • 04:13Microscope-Integrated Optical Coherence Tomography (miOCT)-Guided Foveal Detachment
  • 05:49Removal of Native Retinal Pigment Epithelium
  • 06:21miOCT-Guided Graft Implantation, Position Adjustment, and Subretinal Fluid Drainage
  • 08:33Results: Assessment of the Retinal Pigment Epithelial Graft
  • 10:33Conclusion

Summary

Automatic Translation

由于解剖学和遗传相似性,非人灵长类动物(NHP)是研究人类视网膜细胞疗法的理想模型。本手稿描述了在NHP眼中进行视网膜色素上皮细胞的黄斑下移植方法以及预防与黄斑操作相关的术中并发症的策略。

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