/

/

分子動力学シミュレーションによるEGFR体型変異の活性化の構造効果の解読

JoVE Journal
Biochemistry

This content is Free Access.

JoVE Journal Biochemistry

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Please note that all translations are automatically generated. Click here for the English version.

分子動力学シミュレーションによるEGFR体型変異の活性化の構造効果の解読

7,954 Views

•

15:05 min

•

May 20, 2020

DOI:

10.3791/61125-v

DOI:

10.3791/61125-v

•

15:05 min

May 20, 2020

•

3 Views

Mahlet Z. Tamirat¹, Kari J. Kurppa², Klaus Elenius^2,3,4, Mark S. Johnson¹

¹Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering,Åbo Akademi University, ²Medicity Research Laboratories and Institute of Biomedicine,University of Turku, ³Turku Bioscience Centre,University of Turku and Åbo Akademi University, ⁴Department of Oncology and Radiotherapy,University of Turku and Turku University Hospital

Summary

このプロトコルの目的は、分子動力学シミュレーションを用いて、EGFRキナーゼタンパク質の活性化変異に起因する動的構造変化を調べることである。

Explore More Videos

Molecular Dynamics Simulation EGFR Somatic Mutations Protein Structure Kinase Conformational Changes Ligand Binding Cancer Wild-type Deletion Mutant Active Inactive Asymmetric Dimer Kymera Protein Data Bank Modeling

Read Article