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Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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May 20, 2020
DOI:
1Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering,Åbo Akademi University, 2Medicity Research Laboratories and Institute of Biomedicine,University of Turku, 3Turku Bioscience Centre,University of Turku and Åbo Akademi University, 4Department of Oncology and Radiotherapy,University of Turku and Turku University Hospital
Summary
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The objective of this protocol is to use molecular dynamics simulations to examine the dynamic structural changes that occur due to activating mutations of the EGFR kinase protein.
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Tamirat, M. Z., Kurppa, K. J., Elenius, K., Johnson, M. S. Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation. J. Vis. Exp. (159), e61125, doi:10.3791/61125 (2020).
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