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通过分子动力学模拟破译激活EGFR体电突变的结构效应

JoVE Journal
Biochemistry

This content is Free Access.

JoVE Journal Biochemistry

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

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通过分子动力学模拟破译激活EGFR体电突变的结构效应

7,957 Views

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15:05 min

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May 20, 2020

DOI:

10.3791/61125-v

DOI:

10.3791/61125-v

•

15:05 min

May 20, 2020

•

3 Views

Mahlet Z. Tamirat¹, Kari J. Kurppa², Klaus Elenius^2,3,4, Mark S. Johnson¹

¹Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering,Åbo Akademi University, ²Medicity Research Laboratories and Institute of Biomedicine,University of Turku, ³Turku Bioscience Centre,University of Turku and Åbo Akademi University, ⁴Department of Oncology and Radiotherapy,University of Turku and Turku University Hospital

Summary

该协议的目的是利用分子动力学模拟来检查由于EGFR激酶蛋白的激活突变而发生的动态结构变化。

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