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Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
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Neuroscience
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JoVE Journal Neuroscience
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

English

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2,811 Views

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08:55 min

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April 24, 2020

DOI:

10.3791/61006-v

DOI:
10.3791/61006-v

•

08:55 min
April 24, 2020

•

11 Views
, , ,
1North Texas Eye Research Institute, Department of Pharmacology and Neuroscience,University of North Texas Health Science Center, 2Mechanical Engineer Consultant, 3Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health,University of Wisconsin

Summary

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We describe and detail the use of the translaminar autonomous system. This system utilizes the human posterior segment to independently regulate the pressure inside the segment (intraocular) and surrounding the optic nerve (intracranial) to generate a translaminar pressure gradient that mimics features of glaucomatous optic neuropathy.

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Cite this Article

Sharma, T. P., Curry, S. M., Lohawala, H., McDowell, C. Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments. J. Vis. Exp. (158), e61006, doi:10.3791/61006 (2020).

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