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Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
JoVE Journal
Medicine
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JoVE Journal Medicine
Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

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14,541 Views

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07:40 min

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March 20, 2021

DOI:

10.3791/60776-v

DOI:
10.3791/60776-v

•

07:40 min
March 20, 2021

•

50 Views
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1Translational Medicine, R&D Oncology,AstraZeneca, 2Acerta Pharma, AstraZeneca Group, 3Translational Medicine, R&D Oncology,AstraZeneca

Summary

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This protocol details clinically implementable preparation of high quality PBMC and plasma biosamples at the clinical trial site that can be used for translational biomarker analysis.

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Marco-Casanova, P., Lukashchuk, N., Lombardi, B., Munugalavadla, V., Frigault, M. M., Harrington, E. A., Barrett, J. C., Pierce, A. J. Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis. J. Vis. Exp. (169), e60776, doi:10.3791/60776 (2021).

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