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L’analyse de déplacement de la déformation mécanique myocardique (DIAMOND) révèle l’hétérogénéité segmentale de la fonction cardiaque chez le poisson zèbre embryonnaire
JoVE Journal
Developmental Biology
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JoVE Journal Developmental Biology
Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish
DOI:

09:15 min

February 06, 2020

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Chapters

  • 00:04Introduction
  • 01:13Reconstruction of the 3D Systolic and Diastolic Heart and Segmentation of the Ventricle
  • 02:41Creation of Rectangular Parallelepipeds for Image Registration and Resampling of Systolic and Diastolic 3D Hearts Along the Short Axis Plane
  • 05:01Division of the Resampled Heart
  • 06:20Registration of Systolic and Diastolic Image Matrices and Output of Displacement Vectors
  • 07:01Results: Segmental Heterogeneity in Cardiac Function and Susceptibility to Chemotherapy-induced Injury
  • 08:45Conclusion

Summary

Automatic Translation

Le but de ce protocole est de détailler une nouvelle méthode pour l’évaluation de la fonction cardiaque segmentale chez le poisson zèbre embryonnaire dans des conditions physiologiques et pathologiques.

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