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Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice
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Neuroscience
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JoVE Journal Neuroscience
Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice

Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice

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10,653 Views

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08:57 min

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August 10, 2019

DOI:

10.3791/60028-v

DOI:
10.3791/60028-v

•

08:57 min
August 10, 2019

•

4 Views
, ,
1Department of Psychiatry,University of Texas Southwestern Medical Center, 2Department of Neuroscience,University of Texas Southwestern Medical Center

Summary

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This protocol describes the construction of a hybrid microdrive array that allows implantation of nine independently adjustable tetrodes and one adjustable opto-silicon probe in two brain regions in freely moving mice. Also demonstrated is a method for safely recovering and reusing the opto-silicon probe for multiple purposes.

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Cite this Article

Osanai, H., Kitamura, T., Yamamoto, J. Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice. J. Vis. Exp. (150), e60028, doi:10.3791/60028 (2019).

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