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Generazione di fibrille preformate alfa-sinucleina da monomeri e uso in vivo
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June 02, 2019
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1Department of Translational Science and Molecular Medicine,Michigan State University, 2The Michael J. Fox Foundation for Parkinson’s Research, 3Neuroscience Program,Michigan State University, 4Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine,University of Pennsylvania Perelman School of Medicine, 5Center for Neurodegeneration and Experimental Therapeutics,University of Alabama at Birmingham, 6Mercy Health Hauenstein Neuroscience Medical Center
Summary
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L'obiettivo di questo articolo è quello di delineare i passi necessari per la generazione di fibrille da alfa-sinucleina monomerica, successivo controllo di qualità, e l'uso dei fibrili preformati in vivo.
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Patterson, J. R., Polinski, N. K., Duffy, M. F., Kemp, C. J., Luk, K. C., Volpicelli-Daley, L. A., Kanaan, N. M., Sortwell, C. E. Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo. J. Vis. Exp. (148), e59758, doi:10.3791/59758 (2019).
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