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JoVE Journal Neuroscience
Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo
 

Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo

Article DOI: 10.3791/59758-v • 09:44 min • June 2nd, 2019
June 2nd, 2019 •
1, 2, 1,3, 1, 4, 5, 1, 1,3,6
1Department of Translational Science and Molecular Medicine, Michigan State University, 2The Michael J. Fox Foundation for Parkinson's Research, 3Neuroscience Program, Michigan State University, 4Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 5Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 6Mercy Health Hauenstein Neuroscience Medical Center

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The goal of this article is to outline the steps required for the generation of fibrils from monomeric alpha-synuclein, subsequent quality control, and use of the preformed fibrils in vivo.

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Alpha-Synuclein Preformed Fibrils Synucleinopathies Pathology Neurodegeneration Parkinson's Disease Motor Impairments Inclusions Phosphorylated Alpha-synuclein Therapeutic Interventions Glass Needles Alpha-synuclein Monomers Centrifuge DPBS
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