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A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
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May 15, 2019
DOI:
1Department of Anatomy and Convergence Medical Sciences, Institute of Health Sciences, Bio Anti-aging Medical Research Center,Gyeongsang National University Medical School, 2Department of Biological Sciences,Pusan National University, 3Department of Physiology and Convergence Medical Sciences, Institute of Health Sciences,Gyeongsang National University Medical School
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This article provides a simplified and standardized protocol for induction of depressive-like behavior in chronically immobilized mice by using a restrainer. In addition, behavior and physiological techniques to verify induction of depression are explained.
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Son, H., Yang, J. H., Kim, H. J., Lee, D. K. A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice. J. Vis. Exp. (147), e59546, doi:10.3791/59546 (2019).
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