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Identificatie van bemiddelaars/Mediators van T-cel Receptor signalering via de Screening van chemische remmer bibliotheken
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Identificatie van bemiddelaars/Mediators van T-cel Receptor signalering via de Screening van chemische remmer bibliotheken

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8,799 Views

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08:49 min

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January 22, 2019

DOI:

10.3791/58946-v

DOI:
10.3791/58946-v

•

08:49 min
January 22, 2019

•

3 Views
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1Department of Microbiology and Immunology, Yong Loo Lin School of Medicine,National University of Singapore, 2Singapore Immunology Network,A*STAR, 3Curiox Biosystems, 4Department of Immunobiology, Rega Institute for Medical Research,Katholieke Universiteit (KU) Leuven

Summary

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Deze paper gebruikt een stroom cytometry-gebaseerde assay naar scherm bibliotheken van chemische inhibitoren voor de identificatie van remmers en de bijbehorende doelen die van invloed zijn T-cel receptor signalering. De hier beschreven methoden kunnen ook worden uitgebreid voor high-throughput screening.

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Cite this Article

Chen, E. W., Ke, C. Y., Brzostek, J., Gascoigne, N. R. J., Rybakin, V. Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries. J. Vis. Exp. (143), e58946, doi:10.3791/58946 (2019).

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