Journal
/
Neurosciences
/
Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries
Journal JoVE
Neurosciences
This content is Free Access.
Journal JoVE Neurosciences
Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

6,889 Views

•

08:21 min

•

April 01, 2019

DOI:

10.3791/58792-v

DOI:
10.3791/58792-v

•

08:21 min
April 01, 2019

•

3 Views
, , , , ,
1Charles R. Allen Research Laboratories, Department of Anesthesiology,University of Texas Medical Branch, 2The Moody Project for Translational Traumatic Brain Injury Research,University of Texas Medical Branch

Summary

Automatically generated

Here, we present a protocol to describe methods for ex vivo vascular reactivity determination following a primary blast traumatic brain injury (bTBI) using isolated, pressurized, rodent middle cerebral arterial (MCA) segments. bTBI induction is accomplished using a shock tube, also known as an Advanced Blast Simulator (ABS) device.

Explore More Videos

Blast-induced NeurotraumaPressurized Rodent Middle Cerebral ArteriesCerebral Vascular InjuryMyogenic Vascular ResponseIsolated Pressurized Arterial PreparationAdvanced Blast SimulatorMylar SheetsHydraulic Hand PumpAnesthetized RatEndotracheal TubeVentilatorSpecimen TrayHeat LampScalpEar Plug

Read Article

Cite this Article

Rodriguez, U. A., Zeng, Y., Parsley, M. A., Hawkins, B. E., Prough, D. S., DeWitt, D. S. Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries. J. Vis. Exp. (146), e58792, doi:10.3791/58792 (2019).

Download .ris file

Copy

Share Video

.

Copy