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小角度 x 射线散射溶液中大分子的结构研究

JoVE Journal
Biochemistry

This content is Free Access.

JoVE Journal Biochemistry

Structural Studies of Macromolecules in Solution using Small Angle X-Ray Scattering

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小角度 x 射线散射溶液中大分子的结构研究

12,094 Views

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07:19 min

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November 05, 2018

DOI:

10.3791/58538-v

DOI:

10.3791/58538-v

•

07:19 min

November 05, 2018

•

7 Views

Tyler Mrozowich¹, Steffane McLennan², Michael Overduin^2,4, Trushar R. Patel^1,3,4

¹Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry,University of Lethbridge, ²Department of Biochemistry,University of Alberta, ³Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine,University of Calgary, ⁴DiscoveryLab, Faculty of Medicine & Dentistry,University of Alberta

Summary

在这里, 我们介绍了如何利用小角度 x 射线散射 (saxs) 来获取代表大分子结构的低分辨率信封的信息。当与 x 射线晶体学和核磁共振等高分辨率结构技术结合使用时, saxs 可以提供对多域蛋白质和高分子复合物溶液的详细洞察。

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