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Structural Studies of Macromolecules in Solution using Small Angle X-Ray Scattering
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November 05, 2018
DOI:
1Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry,University of Lethbridge, 2Department of Biochemistry,University of Alberta, 3Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine,University of Calgary, 4DiscoveryLab, Faculty of Medicine & Dentistry,University of Alberta
概要
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Here, we present how Small Angle X-Ray Scattering (SAXS) can be utilized to obtain information on low-resolution envelopes representing the macromolecular structures. When used in conjunction with high-resolution structural techniques such as X-Ray Crystallography and Nuclear Magnetic Resonance, SAXS can provide detailed insights into multidomain proteins and macromolecular complexes in-solution.
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Mrozowich, T., McLennan, S., Overduin, M., Patel, T. R. Structural Studies of Macromolecules in Solution using Small Angle X-Ray Scattering. J. Vis. Exp. (141), e58538, doi:10.3791/58538 (2018).
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