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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

DOI:
10.3791/57167-v

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06:51 min

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July 21, 2018

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, , , , , , , ,
1Division of Pulmonary and Critical Care Medicine,University of California Los Angeles David Geffen School of Medicine, 2University of North Carolina at Chapel Hill, 3Department of Molecular and Medical Pharmacology,University of California Los Angeles, 4Andor Technology, 5Division of Orthopaedic Surgery,University of California Los Angeles David Geffen School of Medicine

Chapters

  • 00:04Title
  • 00:4718F-FDG PET and CT Imaging in Mice
  • 04:06Image Processing
  • 05:09Results: 18F-FDG PET Identifies Metabolically Active Lung Tumors
  • 06:16Conclusion

Summary

Automatic Translation

Automatic Translation

In this protocol, we describe how to utilize [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (18F-FDG PET/CT) imaging to measure the tumor metabolic response to the targeted therapy MLN0128 in a Kras/Lkb1 mutant mouse model of lung cancer and coupled imaging with high resolution ex vivo autoradiography and quantitative histology.

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Keywords: 18F-FDG PET/CTLung CancerTumor MetabolismCancer TherapeuticsQuantitative HistologyNon-invasive ImagingMouse Model

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