Journal
/
Recherche en cancérologie
/
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Journal JoVE
Recherche en cancérologie
This content is Free Access.
Journal JoVE Recherche en cancérologie
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

16,952 Views

•

06:51 min

•

July 21, 2018

DOI:

10.3791/57167-v

DOI:
10.3791/57167-v

•

06:51 min
July 21, 2018

•

4 Views
, , , , , , , ,
1Division of Pulmonary and Critical Care Medicine,University of California Los Angeles David Geffen School of Medicine, 2University of North Carolina at Chapel Hill, 3Department of Molecular and Medical Pharmacology,University of California Los Angeles, 4Andor Technology, 5Division of Orthopaedic Surgery,University of California Los Angeles David Geffen School of Medicine

Summary

Automatically generated

In this protocol, we describe how to utilize [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (18F-FDG PET/CT) imaging to measure the tumor metabolic response to the targeted therapy MLN0128 in a Kras/Lkb1 mutant mouse model of lung cancer and coupled imaging with high resolution ex vivo autoradiography and quantitative histology.

Explore More Videos

18F-FDG PET/CTLung CancerTumor MetabolismCancer TherapeuticsQuantitative HistologyNon-invasive ImagingMouse Model

Read Article

Cite this Article

Momcilovic, M., Bailey, S. T., Lee, J. T., Zamilpa, C., Jones, A., Abdelhady, G., Mansfield, J., Francis, K. P., Shackelford, D. B. Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer. J. Vis. Exp. (137), e57167, doi:10.3791/57167 (2018).

Download .ris file

Copy

Share Video

.

Copy