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A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice
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Immunology and Infection
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JoVE Journal Immunology and Infection
A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

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11,196 Views

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07:38 min

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April 13, 2018

DOI:

10.3791/56443-v

DOI:
10.3791/56443-v

•

07:38 min
April 13, 2018

•

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1Corporate Preclinical R&D,Chiesi Farmaceutici S.p.A., 2Department of Veterinary Science,University of Parma, 3Department of Molecular Genetics,Erasmus MC, 4Department of Molecular Genetics, Vascular Surgery, Radiation Oncology,Erasmus MC, 5Fluidda NV

Summary

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We describe a non-invasive multimodal imaging approach based on Micro-CT and fluorescence molecular tomography for longitudinal assessment of the mouse lung fibrosis model induced by double intratracheal instillation of bleomycin.

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Micro-CTFluorescence Molecular TomographyLung FibrosisIPFMouse ModelLongitudinal AssessmentNon-invasive ImagingBleomycinProbe InjectionData AcquisitionImaging Cassette

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Ruscitti, F., Ravanetti, F., Donofrio, G., Ridwan, Y., van Heijningen, P., Essers, J., Villetti, G., Cacchioli, A., Vos, W., Stellari, F. F. A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice. J. Vis. Exp. (134), e56443, doi:10.3791/56443 (2018).

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