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A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice
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Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

DOI:
10.3791/56443-v

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07:38 min

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April 13, 2018

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, , , , , , , , ,
1Corporate Preclinical R&D,Chiesi Farmaceutici S.p.A., 2Department of Veterinary Science,University of Parma, 3Department of Molecular Genetics,Erasmus MC, 4Department of Molecular Genetics, Vascular Surgery, Radiation Oncology,Erasmus MC, 5Fluidda NV

Capitoli

  • 00:04Titolo
  • 00:56Intratracheal Administration of Bleomycin
  • 01:46Probe Injection for Fluorescence Molecular Tomography
  • 02:25Fluorescence Molecular Tomography Imaging
  • 03:45In Vivo Imaging by Micro-CT
  • 05:45Results: Time-course and Quantification of Bleomycin-induced Lung Fibrosis
  • 07:09Conclusion

Summary

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We describe a non-invasive multimodal imaging approach based on Micro-CT and fluorescence molecular tomography for longitudinal assessment of the mouse lung fibrosis model induced by double intratracheal instillation of bleomycin.

Tags

Micro-CTFluorescence Molecular TomographyLung FibrosisIPFMouse ModelLongitudinal AssessmentNon-invasive ImagingBleomycinProbe InjectionData AcquisitionImaging Cassette

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