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Large Volume, Behaviorally-relevant Illumination for Optogenetics in Non-human Primates
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JoVE Journal Behavior
Large Volume, Behaviorally-relevant Illumination for Optogenetics in Non-human Primates

Large Volume, Behaviorally-relevant Illumination for Optogenetics in Non-human Primates

DOI:
10.3791/56330-v

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08:32 min

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October 03, 2017

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, , ,
1McGovern Institute,Massachusetts Institute of Technology, 2Harvard-MIT Division of Heath Sciences and Technology, 3Department of Anesthesiology,Duke University Medical Center, 4Department of Biology,Massachusetts Institute of Technology, 5Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy,University of North Carolina at Chapel Hill, 6Media Lab and Department of Biological Engineering,Massachusetts Institute of Technology, 7Department of Brain and Cognitive Sciences,Massachusetts Institute of Technology

Chapters

  • 00:05Title
  • 01:03Illuminator Fabrication
  • 05:09In Vivo Illumination
  • 07:07Results: Behavioral and Electrophysiological Effects of Optogenetic Inhibition with Large Volume Illumination
  • 07:32Conclusion

Summary

Automatic Translation

Automatic Translation

A protocol to build a tissue penetrating illuminator for delivering light over large volumes with minimal diameter is presented.

Tags

Keywords: OptogeneticsNon-human PrimatesNeuronal FiringTranslational MedicinePlastic Optical FiberHeat GunFiber ThinningConstant Tension

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