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A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation
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Developmental Biology
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JoVE Journal Developmental Biology
A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation

A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation

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12,839 Views

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08:46 min

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July 26, 2017

DOI:

10.3791/56114-v

DOI:
10.3791/56114-v

•

08:46 min
July 26, 2017

•

6 Views
, ,
1Department of Life Sciences,Peking University, 2National Institute of Biological Sciences, Beijing, 3Graduate School of Peking Union Medical College

Summary

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Internal lung surface area (ISA) is a critical criterion for assessing lung morphology and physiology in lung diseases and injury-induced alveolar regeneration. We describe here a standardized method that can minimize the measurement bias for ISA in both lung pneumonectomy and prosthesis implantation mouse models.

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Keyword Extraction:Mouse PneumonectomyProsthesis ImplantationInternal Lung Surface AreaLung FunctionMechanical Force-induced Adult Lung RegenerationTracheal IntubationThoracotomyLeft Lung Lobe RemovalPulmonary Artery And Bronchi LigationChest Wall ClosurePost-operative Care

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Cite this Article

Liu, Z., Fu, S., Tang, N. A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation. J. Vis. Exp. (125), e56114, doi:10.3791/56114 (2017).

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